ICIP 2006, Atlanta, GA
 

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Paper Detail

Paper:MA-P4.2
Session:Image Registration/Alignment and Mosaicking
Time:Monday, October 9, 09:40 - 12:20
Presentation: Poster
Topic: Interpolation and Super-Resolution: Registration / alignment
Title: IMAGE REGISTRATION OF DIFFERENTLY STAINED HISTOLOGICAL SECTIONS
Authors: Jens-Peer Kuska; University Leipzig 
 Ulf-Dietrich Braumann; University Leipzig 
 Nico Scherf; University Leipzig 
 Markus Löffler; University Leipzig 
 Jens Einenkel; University Leipzig 
 Michael Höckel; University Leipzig 
 Lars-Christian Horn; University Leipzig 
 Nicolas Wentzensen; University Heidelberg 
 Magnus von Knebel Doeberitz; University Heidelberg 
Abstract: We have focused our interest on the registration of brightfield transmitted light microscopy images with respect to different histological stainings. For this kind of registration problem we have developed a new segmentation procedure. Based on the obtained consistent segmentations, a nonlinear registration transformation is computed. The applied registration procedure uses a curvature-based nonlinear partial differential equation in order to find the appropriate mapping between the images. We present an example for the registration of images of two consecutive histological sections from a uterine cervix specimen, where one section stained with p16^INK4a was mapped onto another with H&E staining. Finally, we give an illustrative example for a tissue volume reconstruction based on an alternately stained large serial section.